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Matrix Genomics

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genetic knowledge

Inherited Risk for Parkinson's Disease 'LRRK2 Signature'

Parkinson's Disease

LRRK2 signature

Whether or not you have inherited a high risk signature in the LRRK2 gene it reported. The infrequent p.G2019S mutation, and other mutations, are not detected. The test was developed to assess predisposition among white persons of European ancestry.

This is not a diagnostic test and does not indicate the presence or absence of Parkinson's Disease. A test result is not an absolute indicator that a person will or will not develop PD.

A genetic signature in the LRRK2 gene indicates elevated risk for Parkinson's disease

Parkinson's disease is the second most common neurodegenerative disease, after Alzheimer's disease, affecting about 1% of persons over the age of 50. It is caused by many factors both inherited and related to lifestyle & environmental exposures such as pesticides.

Our assessment of inherited predisposition to Parkinson's disease evaluates a number of locations within the LRRK2 gene in order to determine whether or not a specific genetic signature is present. This signaure is found in a third of patients, and less common in the population. Click here for detailed information.

This signature is either present (3-fold elevated risk) or absent.

While the test defines an important risk factor for Parkinson's disease, no claim is made that all relevant genes are tested. Other low frequency forms of LRRK2 also appear to multiply the risk of Parkinson's disease. The p.G2019S mutation in LRRK2 found in about 2% of cases is not evaluated. Further, the presence of this signature does not guarantee that you will develop Parkinson's disease, nor does the absence of this signature guarantee that you will never develop Parkinson's disease. We hope that you share this information with your physician, who is welcome to contact us.

Parkinson's Disease Links